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apalutamide will decrease the extent or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medications which can be CYP3A4 substrates may result in lower exposure to these medications.Allergic reactions such as rash, angioedema, ana